Adam Ralph was gracious enough to spend some time with me explaining NancyFX, an open source project for creating "lightweight, low-ceremony, framework for building HTTP based services on .Net and Mono." It is so lightweight, in fact, that Adam builds an entire web application using ScriptCS, a text editor, and his wits using this interesting framework. I've heard great things about the Nancy community as well.
Web development is in a state of confusion. We feel we are not innovating enough, we are let down by browsers and OSes and we try to fill all these holes with home made remedies. It's time to look at what we have, what we lost and what is a waste of our time.