This presentation discusses Microsoft Application Virtualization (App-V) infrastructure design and lessons learned from a series of customer deployments. Topics include Management and Reporting Server design, Shared Content placement/replication, Publishing Server placement, load balancing options, Rapid Scale-out solutions, sizing calculations, and data store configuration options. Examples for using Windows PowerShell to automate and bridge product gaps are demonstrated. Use cases discussed include Published Desktops vs. Applications, VDI Density Reduction, and IOPS/Application Footprint Reduction.